A. Androgens and antiandrogens Adverse effects due largely to their masculinizing actions and are most noticeable in women and prepubertal children (1) Sex dysfunction: virilisation in female (hirsutism acne amenorrhea, clitoral enlargement, and deepening of the voice, testosterone> 200-300 mg of per month) o increased libido in male (2) Hepatic toxicity occurs early in the course of treatment, the degree is proportionate to the dose bilirubin levels tAdverse effects - due largely to their masculinizing actions and are most noticeable in women and prepubertal children. (1) Sex dysfunction: • virilisation in female(hirsutism, acne, amenorrhea, clitoral enlargement, and deepening of the voice, testosterone> 200–300 mg of per month) • increased libido in male (2) Hepatic toxicity • occurs early in the course of treatment, the degree is proportionate to the dose. bilirubin levels ↑ A. Androgens and antiandrogens