1440 Fu et al of diseases affecting the central nervous system, such as recognition of the scorpion toxin maurotoxin schizophrenia, have been selected and are undergoing further potassium ion channels. Biophys J. 83: 2370-23 experimental testing(W. Fu, W. Zhu, and H. Jiang, unpub- 3. Ory, A. and B. A. Wallace. 2000. Modeling and docking the lished data) 14. Perera, L, C. Foley, T. A. Darden, D. Stafford, T. Mather, C. mon,and L. G. Pedersen. 2000. Modeling zymogen protein Biophys.J.792925-2943 SUPPLEMENTARY MATERIAL 15. Huang, X.Q., J. H. Shen, M. Cui, L. L. Shen, X. M. luo, K. ling, To view all of the supplemental files associated with this G. Pei, H. L. Jiang, and K. X. Chen. 2003. Molecular dyna mulations on SDF-lc nding with CXCR4 receptor. BiophysJ. articlevisitwww.biophysj.org 171-184 We express gratitude to Dr. Lingling Shen(Max Planck Institute), Dr. Jian 16. Filizola, M, M. Carteni-Farina, and J.J. Perez. 1999. Modeling the 3D structure of rhodopsin using a de novo approach to build G-protein Zhang(Shanghai Institute of Material Medica) and to Prof J. A Javitch coupled receptors. J. Phys. Chem. B. 103: 2520-252 Columbia University, Medical Center) for their helpful discussions. 17. Palczewski, K. T. Kumasaka, T. Hori. C. A. Behnke, H. Mot We gratefully acknowledge financial support from the State Key Program B. A Fox, I Le Trong. D. C. Teller, T. Okada, R. E. Stenkamp M of Basic Research of China(grant 2002CB512802, 2004CB5 18901)and Yamamoto, and M. Miyano. 2000. Crystal structure of rhodopsin: a G Shanghai Science and Technology Commission (05JC14092). We also rotein-coupled receptor. Science. 289: 730-734 xpress gratitude for partial support of this work(to J.M.B. )from the 18. Baker, D- and A Sali. 2001. Protein structure prediction and structural National Aeronautics and Space Administration through the University genomics. 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