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D1 Agonist and D2 Antagonist Dual Effect of SPD 144 34. Berendsen, H.J. C, J. P. M. Postma, W. F. Gunsteren, A. DiNola, and 45. Peng, C, P. Y. Ayala, H. B. Schlegel, and M. J. Frisch. 1996. Using J. R. Haak. 1984. Molecular-dynamics with coupling to an extemal redundant internal coordinates to optimize geometries and transition bath. J. Chem. Phys. 81: 3684-3690 states.j.comp.Chem17:49-56 35. Essmannetal, U, L. Perera, M. L. Berkowitz. T. Darden, H. Lee, and 46. Case D. A.T. E. Cheatham Ill. T Darden. H. Gohlke R. Luo K. M. L. G. Pedersen. 1995. A smooth particle mesh Ewald method.J. Chem Merz, B. Wang, and R. Woods. 2005. The amber biomolecular simula- Phys.103:8577-8593 tionprogramsJ.compuTatChem.26:1668-1688 36. Xuan, J C, G. D. Lin, G. Z. Jin, and Y. Chen. 1988. Relevance of 47. Amadei. A. A. B. Linssen, and H. J. Berendsen. 1993. Essential ereo and quantum chemistry of four tetrahydroprotoberberines to dynamics of proteins. 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