浙医一院 Pathogenesy of PU--Acid Pepsine Pepsine Maxim um activity of enzyme%) rely on Acid o no acid no ulcer 60 parietal cell mass parietal sensibility feedback suppression 1 2 3 Gastric fluid pH e vagal tonePathogenesy of PU—Acid & Pepsine 0 20 40 60 80 100 Maximum activity of enzyme(%) 1 2 3 Gastric fluid pH 4 2 4 Pepsine rely on Acid no acid,no ulcer parietal cell mass parietal sensibility feedback suppression vagal tone