Mucosal damage 浙医一院 Pathogenesy of pu .Acid and pepsine .Helicobacter pylori NSAIDs .Motility disturbance Stress .Systemic inflammatory disorders . schemia Hypergastrinemic Syndromes .Hyperhistaminic syndromes Anastomotic or marginal Ulceration Alcohol TobaccoMucosal damage Pathogenesy of PU •Acid and Pepsine •Helicobacter pylori •NSAIDs •Motility disturbance •Stress •Systemic inflammatory disorders •Ischemia •Hypergastrinemic Syndromes •Hyperhistaminic Syndromes •Anastomotic or marginal Ulceration •Alcohol •Tobacco