Syntheses of the Aldehydes and Ketones(Recap?) From Alcohols (Ch 11) Secondary alcohols are readily oxidized to ketones by Chromic acid (or KmnO4). Na2Cr2O7 H2S04 borneol camphor Complicated ketones can be made by the oxidation of alcohols,which in turn can be made from reaction of a Grignard and an aldehyde OH Na2Cr207 0 R-MgBr R-C-H- R'-C-H 分 H2S04 R'-C-R Aldehydes are made from the oxidation of primary alcohols.This oxidation needs to be done carefully to avoid overoxidation to carboxylic acids. PCC CH2-OH CHO This is achieved by the use of PCC Chl8 Ketones and Aldehydes (landscape) Page 6Ch18 Ketones and Aldehydes (landscape) Page 6 Syntheses of the Aldehydes and Ketones (Recap?) From Alcohols (Ch 11) Secondary alcohols are readily oxidized to ketones by Chromic acid (or KmnO4). Complicated ketones can be made by the oxidation of alcohols, which in turn can be made from reaction of a Grignard and an aldehyde. Aldehydes are made from the oxidation of primary alcohols. This oxidation needs to be done carefully to avoid overoxidation to carboxylic acids. This is achieved by the use of PCC. H OH O borneol camphor Na2Cr2O7 H2SO4 R MgBr + R' C H O R' C OH R H R' C R O H2SO4 Na2Cr2O7 CH2 -OH CHO PCC