Chromosome Hot Spot a Research by the stefansson et al Based on genome-wide studies of similar populations as Shi et al Studied specific Copy Number Variations (CNVS) CNVS are areas of dna where copy-number differences are found by comparing multiple genomes Can be either inherited or caused by de novo mutations, such as deletions, duplications, inversions or translocations Research by the Stefansson et al: ◼ Based on genome-wide studies of similar populations as Shi et al ◼ Studied specific Copy Number Variations (CNVs) ◼ CNVs are areas of DNA where copy-number differences are found by comparing multiple genomes ◼ Can be either inherited or caused by de novo mutations, such as deletions, duplications, inversions, or translocations