Chromosome Hot Spot a Research by the stefansson et al Based on genome-wide studies of similar populations as Shi et al Studied specific Copy Number Variations (CNVS) CNVS are areas of dna where copy-number differences are found by comparing multiple genomes Can be either inherited or caused by de novo mutations, such as deletions, duplications, inversions or translocations Research by the Stefansson et al: ◼ Based on genome-wide studies of similar populations as Shi et al ◼ Studied specific Copy Number Variations (CNVs) ◼ CNVs are areas of DNA where copy-number differences are found by comparing multiple genomes ◼ Can be either inherited or caused by de novo mutations, such as deletions, duplications, inversions, or translocations