Chromosome Hot Spot a Research by shi et al show Schizophrenia is significant associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6 This region has a histone gene cluster, and also a some genes related to immunity This could imply etiological linkage to Chromatin modification, transcriptional regulation autoimmunity, and/orinfection Research by Shi et al show: ◼ “Schizophrenia is significant associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6” ◼ This region has a histone gene cluster, and also a some genes related to immunity ◼ This could imply etiological linkage to: ◼ Chromatin modification, transcriptional regulation, autoimmunity, and/or infection