Chromosome Hot Spot a In a series of studies published in July 2009 in Nature, a" hot spot was found on chromosome 6p22.1 a On short arm of chromosome 6, at extended MHCregion Has on it a histone gene cluster Related to control of dna transcription and repair Related to antimicrobial defense, immunity Controls when and how genes turn on/off In a series of studies published in July 2009 in Nature, A “hot spot” was found on chromosome 6p22.1  On short arm of chromosome 6, at extended MHC region ◼ Has on it a histone gene cluster ◼ Related to control of DNA transcription and repair ◼ Related to antimicrobial defense, immunity ◼ Controls when and how genes turn on/off