9.1.3 Acute Vs Chronic Inflammation 9.1.3.1 Acute Inflammation Comprises cellular processes, soluble mediators, and vascular changes occurring immediately following injury to vascular tissue and is of relatively short duration(from a few minutes to a few days). The classical clinical signs are: heat, redness, swelling, and pain. In many cases function of the tissue is compromised 9.1.3.2 Chronic Inflammation that cell types and activities associated with a persistent injury or permanent implant, that could continue for months or years 9. 1.3.2.1 Synovium The chronic inflammatory tissue bordering an implant often has the cell composition(macrophages and fibroblasts) and arrangement(cells in mono-or multiple-layer)consistent with synovium, The tissue that lines joints and encapsulates fluid-filled sacs(bursae) 1.3 2.2 Granuloma A focal accumulation of epithelioid cells(macrophages altered in appearance to resemble epithelial cells) and multinucleated giant cells. This term is also applied to collections of lymphocytes surrounded by fibrous tissue 9.1.3. 3 Scar and Contraction9.1.3 Acute Vs. Chronic Inflammation 9.1.3.1 Acute Inflammation Comprises cellular processes, soluble mediators, and vascular changes occurring immediately following injury to vascular tissue and is of relatively short duration (from a few minutes to a few days). The classical clinical signs are: heat, redness, swelling, and pain. In many cases function of the tissue is compromised. 9.1.3.2 Chronic Inflammation Cell types and activities associated with a persistent injury or permanent implant, that could continue for months or years. 9.1.3.2.1 Synovium The chronic inflammatory tissue bordering an implant often has the cell composition (macrophages and fibroblasts) and arrangement (cells in mono- or multiple-layer) consistent with synovium, The tissue that lines joints and encapsulates fluid-filled sacs (bursae). 9.1.3.2.2 Granuloma A focal accumulation of epithelioid cells (macrophages altered in appearance to resemble epithelial cells) and multinucleated giant cells. This term is also applied to collections of lymphocytes surrounded by fibrous tissue. 9.1.3.3 Scar and Contraction