9.1 LOCAL EFFECTS: PROCESSES OF HEALING 9.1.2 Processes of healing Inj Biological Agents Microbial infection Chemical Agents Physical Agents Therma Electrical Mechanical Trauma urge Implant movement Features of healing End result Similar to original tissue Regeneration pall Size of wound No/minimal tissue destruction Resolution Small wound(e. g, incision) Healing by first intention(primary or direct healing) arge Healing by second intention(healing with granulation Vascularity Vascula Inflammation precedes repair or regeneration Nonvascular No inflammation No healing(cornea, meniscus, articular cartilage), regeneration(epidermis), or repair(?) Time Early(e. g, due to surgery) Acute inflammation Late(e. g, due to persistence Chronic inflammation of"injury"associated with presence of an implant) Predominant Cell Types Acute PMN, Leukocytes, Macrophage, Endothelial, Fibroblast Chronic Macrophage, MFBGC, Fibroblast Repair vs. Regeneration9.1 LOCAL EFFECTS: PROCESSES OF HEALING 9.1.2 Processes of Healing Injurious Agents Biological Agents - Microbial infection Chemical Agents Physical Agents - Thermal - Electrical - Mechanical Trauma Surgery Implant movement Features of Healing End Result Similar to original tissue Scar Size of Wound No/minimal tissue destruction Small wound (e.g., incision) Large Vascularity Vascular Nonvascular Time Early (e.g., due to surgery) Late (e.g., due to persistence of "injury" associated with presence of an implant) Predominant Cell Types Acute Chronic Repair vs. Regeneration Regeneration Repair Resolution Healing by first intention (primary or direct healing) Healing by second intention (healing with granulation tissue) Inflammation precedes repair or regeneration No inflammation No healing (cornea, meniscus, articular cartilage), regeneration (epidermis), or repair (?) Acute inflammation Chronic inflammation PMN, Leukocytes, Macrophage, Endothelial, Fibroblast Macrophage, MFBGC, Fibroblast