lI. Regulation of Testis Function Hypothalamic Pituitary-Testis Axis Hypothalamus GnRH GnRH Anterior FSH. LH pituitary Testerone FSH LH Negative Feedback Sertoli yang Mechanism cells Testosterone Inhibin Testosterone Inhibin Spermatogenesis Local regulation in Accessory Secondary sexual testes structures characteristicsII. Regulation of Testis Function • Hypothalamic￾Pituitary-Testis Axis – GnRH – FSH, LH – Testerone • Negative Feedback Mechanism – Testosterone – Inhibin • Local regulation in testes