CH3 CCH, CooCH,CH3 CI CCH. CH3CCH2c—cH Acetoacetic ester 乙酰乙酸乙酯 )NaoCH2CH CH3CCHCOOCH2CH CI CH3 CH3CCH,COOCH,CH Acetoacetic ester 乙酰乙酸乙酯 Nucleophile reagent 1)NaOh ChECH CH3CCH-c——cH 2)H CH3CCH—c—cH 水解 COOCH2 CH3 CooNa COoH 脱羧 heat CH2CCH2+c—cH3 CO 2.4-PentandioneCH3CCH2 O C O CH3 CH3CCH2COOCH2CH3 O 1) NaOCH2CH3 CH3CCHCOOCH2CH3 O - Na + Acetoacetic ester 乙 酰 乙 酸 乙 酯 Nucleophile reagent Cl O CH3 CH3CCH2COOCH2CH3 O Acetoacetic ester 乙 酰 乙 酸 乙 酯 + Cl CCH3 O CH3CCH O COOCH2CH3 1) NaOH 2) H3O + CH3CCH O COONa C CH3CCH O COOH C 脱 羧 水 解 O CH3 O CH3 O CH3 heat - CO2 CH3CCH2 O C O CH3 2,4-Pentandione