CH3 CCH2+CH2COOH CH3CCH2CO0CH2 CH3 Br---CH2CO0C2H5 Acetoacetic ester 乙酰乙酸乙酯 )NaoCH2CH Br--cH2, CH2 CCHCOOCH,CH CH3CCHCOOCH2CH Acetoacetic ester 乙酰乙酸乙酯 Nucleophile reagent I)NaOH 2)H2O CH3CCH—cH2cooc2Hs CH3CCH一cH2 CooNa 水解 CooCH2CH CooNa heat CH3CCH—cH2cooH CH3 CCH,+CH2COOH CO COOH 脱羧CH3 CCH2 O CH2 COOH CH3CCH2COOCH2CH3 O 1) NaOCH2CH3 CH3CCHCOOCH2CH3 O - Na + Acetoacetic ester 乙 酰 乙 酸 乙 酯 Nucleophile reagent SN2 Br CH2COOC2H5 CH3CCH2COOCH2CH3 O Acetoacetic ester 乙 酰 乙 酸 乙 酯 + Br CH2COOC2H5 1) NaOH 2) H3O + CH3CCH O COONa CH2COONa 水 解 CH3CCH O COOCH2CH3 CH2COOC2H5 CH3CCH O COOH CH2COOH heat - CO2 CH3CCH2 O CH2COOH 脱 羧