1/26/2016 Mode of Action for Antifungal Drugs Fungal Cell Wall oal sterol. mannoproteins 81.3 tero-principle sterol in the fungal cell 1日 Inhibiting cell wall synthesis -Inhibit the synthesis of B-glucan Cell chitin Inhibiting nucleic acids synthesis ergosterol -Cytosine analog interferes with RNA synthesis Mode of Action for Antiviral Drugs Mode of Action for Antiviral Drugs Entry and fusion inhibitors -Block the receptors on the host cell that bind to Interference with assembly and release the virus -Block fusion of the virus and cell of viral particles -Protease inhibitors block cleavage of Uncoating.genome integration,and nucleic protein precursors acid synthesis inhibitors Viral exit inhibitors -Prevent viral uncoating Inhibit viral DNA integration into the host -Inhibit neuraminidase,an enzyme required genome for some viruses to bud from the host cell -Nucleoside analogs inhibit RNA or DNA synthesis >1/26/2016 7 Mode of Action for Antifungal Drugs • Disrupting membrane permeability – Interrupt the synthesis of a fungal sterol, ergosterol making the membrane excessively ergosterol, making the membrane excessively permeable – Ergosterol – principle sterol in the fungal cell wall • Inhibiting cell wall synthesis – Inhibit the synthesis of -glucan • Inhibiting nucleic acids synthesis – Cytosine analog interferes with RNA synthesis Fungal Cell Wall • Entry and fusion inhibitors – Block the receptors on the host cell that bind to the virus Mode of Action for Antiviral Drugs – Block fusion of the virus and cell • Uncoating, genome integration, and nucleic acid synthesis inhibitors – Prevent viral uncoating – I hibi i l DNA i i i h h Inhibit viral DNA integration into the host genome – Nucleoside analogs inhibit RNA or DNA synthesis • Interference with assembly and release f i l ti l Mode of Action for Antiviral Drugs of viral particles – Protease inhibitors block cleavage of protein precursors • Viral exit inhibitors – Inhibit neuraminidase an enzyme required Inhibit neuraminidase, an enzyme required for some viruses to bud from the host cell