中国科学院 苏州生物医学工程技术研究所人事教育处 《人才快讯》2012年第三期 地点:清华大学医学科学楼C201 faA: Gang Chen, Ph D.( Department of Radiology and Radiological Sciences, Vanderbilt University Institute of I 报告摘要 Non-human primates have served as an important model for understanding functional organization in humans. The ability to conduct functional magnetic resonance imaging M tudies in monkeys promises to bridge the gap between human functional imaging studies and a large body of anatomical, electrophysiological, and functional optical imaging studies in non-human primates We used a high magnetic field 4. 7 Tesla vertical scanner to perform anatomical and functional MRI in awake macaque monkeys. High-field scanners provide higher blood oxygen level dependent signal(BOLD)and a greater signal-to-noise ratIo(SNR). With a dedicated vertical primate scanner, monkeys may perform better for long scans with a more natural upright position We found that improvements in behavioral training were essential for obtaining greater data stability. After extensive training, the average translational movement decreased from over 500 um to less than 80 um in monkeys. We can reliably detect of sub-millimeter laminar structure, neural activation and permitted MR based mapping of sensory areas in awake non-human primates We also investigated pulsed infrared optical stimulation of cortex in monkeys and its potential for optical controls. In a high field(9. 4 Tesla) scanner we recorded images of primary somatosensory cortex of squirrel monkeys during optical stimulation of a single digit location in area 1. Optical stimulation was introduced via a fiberoptic and a newly developed long-term MR-compatible optical transparent window. We found that optical stimulation evokes significant changes in cerebral blood volume weighted MR signals. Furthermore, we observed that the light stimulation can not only directly drive the stimulated site, but also peripheral cortical activity. Stimulation of a single digit location in area I resulted in focal, digit-specific activation in areas 3b, 2, and possibly 3a. Such activations were confined primarily to the middle layers in these nearby areas. Our data demonstrate that pulse infrared laser excitation, used in conjunction with functional Mri, has the potential to play a key role in the future development of human brain-machine interfaces 清华大学学术报告三: Ultrahigh frequency ultrasound microbeam for biomedical applications 时间:6月22日上午10:30 地点:清华大学生物医学影像研究中心104 f&tA: K. Kirk Shung, Ph D(Department of Biomedical Engineering, University of Southern California) 报告摘要 Ultrahigh frequency(100 MHz- 1 GHz) focused ultrasonic beam or microbeam may find many biomedical applications in addition to imaging. For the furthe er advance of the technology sensitive UHF transducers must be developed. In this talk, conventional and new approaches for the design and fabrications of UHF transducers will be discussed along with ultrasound microbeam applications including single beam acoustic microparticle or cell trapping, and UHF中国科学院 苏州生物医学工程技术研究所人事教育处 《人才快讯》2012 年第三期 8 地点：清华大学医学科学楼 C201 报告人：Gang Chen, Ph.D. (Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, USA) 报告摘要 Non-human primates have served as an important model for understanding functional brain organization in humans. The ability to conduct functional magnetic resonance imaging (MRI) studies in monkeys promises to bridge the gap between human functional imaging studies and a large body of anatomical, electrophysiological, and functional optical imaging studies in non-human primates. We used a high magnetic field 4.7 Tesla vertical scanner to perform anatomical and functional MRI in awake macaque monkeys. High-field scanners provide higher blood oxygen level dependent signal (BOLD) and a greater signal-to-noise ratio (SNR). With a dedicated vertical primate scanner, monkeys may perform better for long scans with a more natural upright position. We found that improvements in behavioral training were essential for obtaining greater data stability. After extensive training, the average translational movement decreased from over 500 um to less than 80 um in monkeys. We can reliably detect of sub-millimeter laminar structure, neural activation and permitted MR based mapping of sensory areas in awake non-human primates. We also investigated pulsed infrared optical stimulation of cortex in monkeys and its potential for optical controls. In a high field (9.4 Tesla) scanner we recorded images of primary somatosensory cortex of squirrel monkeys during optical stimulation of a single digit location in area 1. Optical stimulation was introduced via a fiberoptic and a newly developed long-term MR-compatible, optical transparent window. We found that optical stimulation evokes significant changes in cerebral blood volume weighted MR signals. Furthermore, we observed that the light stimulation can not only directly drive the stimulated site, but also peripheral cortical activity. Stimulation of a single digit location in area 1 resulted in focal, digit-specific activation in areas 3b, 2, and possibly 3a. Such activations were confined primarily to the middle layers in these nearby areas. Our data demonstrate that pulse infrared laser excitation, used in conjunction with functional MRI, has the potential to play a key role in the future development of human brain-machine interfaces. 清 华 大 学 学 术 报 告 三 :Ultrahigh frequency ultrasound microbeam for biomedical applications 时间：6 月 22 日上午 10:30 地点：清华大学生物医学影像研究中心 104 报告人：K. Kirk Shung, Ph.D. (Department of Biomedical Engineering, University of Southern California) 报告摘要 Ultrahigh frequency (100 MHz – 1 GHz) focused ultrasonic beam or microbeam may find many biomedical applications in addition to imaging. For the further advance of the technology, sensitive UHF transducers must be developed. In this talk, conventional and new approaches for the design and fabrications of UHF transducers will be discussed along with ultrasound microbeam applications including single beam acoustic microparticle or cell trapping, and UHF ultrasonic cell sorting