Ans:B Chemokines are small cytokines that mediate chemotaxis of immune cells.Bradykinin and histamine are both comnounds that increase vascular nermeability to allow for leukocyte extravasation from the blood vessels into the interstitial tissues.C3a is a complement protein that activates mast cell degranulation.Prostaglandins are potent local lipid molecules that play a role in vascular dilation calcium movement inflammation modulation cell growth and platelet aggregation (to name a few) 3 A 53-vear-old wor man has had a high fever and cough productive of yellowish sputum for the past 2 days.On auscultation of the chest,crackles are audible in both lung bases.A chest shows bilat ral n infiltrates.An intern recently graduated from Duke .What is the major inflammatory cell type? Langhans cells ymphocytes Macrophages D.Mast cells E.Neutrophils Ans:E Many of the cells seen above have multi-lobed nclei.Also.presence ofyellowish sputum implies pus formation,which is a product of acute inflammation characterized by ongoing neutrophilic invasion.Langerhans cells are specialized dendritic cells of the skin and mucosa that are most often seen in the stratum spinosum of the epidermis.Lymphocytes are small cells (about the sixe -2- 2 - Ans: B Chemokines are small cytokines that mediate chemotaxis of immune cells. Bradykinin and histamine are both compounds that increase vascular permeability to allow for leukocyte extravasation from the blood vessels into the interstitial tissues. C3a is a complement protein that activates mast cell degranulation. Prostaglandins are potent local lipid molecules that play a role in vascular dilation, calcium movement, inflammation modulation, cell growth, and platelet aggregation (to name a few). 3. A 53-year-old woman has had a high fever and cough productive of yellowish sputum for the past 2 days. On auscultation of the chest, crackles are audible in both lung bases. A chest radiograph shows bilateral patchy pulmonary infiltrates. An intern recently graduated from Duke obtains a lung biopsy, which is shown above. What is the major inflammatory cell type? A. Langhans cells B. Lymphocytes C. Macrophages D. Mast cells E. Neutrophils Ans: E Many of the cells seen above have multi-lobed nuclei. Also, presence of yellowish sputum implies pus formation, which is a product of acute inflammation characterized by ongoing neutrophilic invasion. Langerhans cells are specialized dendritic cells of the skin and mucosa that are most often seen in the stratum spinosum of the epidermis. Lymphocytes are small cells (about the sixe