·1220 北京科技大学学报 2001年第2期 PVA-H/316LS.S.高载时的摩擦因数小于低载时 Wear of Ultra-high Molecular Weight Polyethylene 的摩擦因数，PVA-H/PVA-H高载时的摩擦因数 Sliding Against Prosthetic Joint Materials.Wear, 大于低载时的摩擦因数，两者均属于混合润滑. 1998,216:213 6 Sawae Y,Murakami T.Effect of Serum Roteins on Fric- (4)r球蛋白和La-DPPC在高载荷时可以 tion and Wear of Prothetic Joint Materials,Proceedings of 明显改善润滑性能.其中，La-DPPC的影响更为 ASIATRIB,1998.828 显著 7 Ahlroos T,Saikko V.Wear of Prosthetic Joint Materials (5)相对于30%小牛血清，PVA-H/PVA-H in Various Lubricants,Elsevier.Wear,1997,211:113 在复合人工滑液润滑下，磨损系数有大幅 8 Murakami T,Sawae Y.The Adaptive Multimode Lubri- 度的降低，最高时降低了2个数量级，达到了 cation in Knee Prostheses with Artificial Cartilage During Walking.in:D.Dowson et al.Ed.Elastohydrodynamics 10-/mm.N-'.m-). '96Elsevier Science B V,1997.371 参考文献 9李久青，顾正秋，肖久梅，等，透明质酸对人工关节材 料的润滑作用.北京科技大学学报，2000,22(4)：343 1顾其胜，王文斌，吴萍.医用透明质酸钠在临床中的 10 Gu zhengqiu,Xiao Jiumei,Zhang Xianghong.The Devel- 应用综述.中国修复重建外科杂志，1998,12(2)：5 opment of Artificial Articular Cartilage-PVA-Hydrogel. 2 Unsworth A,Dowson D,Wright V.Some New Evidence Bio-medical Materials and Engineering,1998,8:75 on Human Joint Lubrication.Ann Rheum Dis,1975,34: 277 11杨抚华，医学细胞生物学概论.成都：四川科学技术 出版杜，1985.24 3 Ikeuchi K.The Role of Synovial Fluid in Joint Lubrica- 12 Murakami T,Higaki H.Adaptive Multimode Lubrication tion.in:D.Dowson et al.editors.Tribology Series 30,Lub- in Natural Synovial Joints and Artificial Joints.Proc Instn ricats and Lubrication Elsevier Science B V.1995.65 Mech Engrs,1998,21(2):Part H,23 4 Murakami T.The Lubrication in Natural Synovial Joints 13 Higaki H,Murakami T.The Lubricating Ability of Bio- and Joint Prostheses.JSME International Journal,Series membrane Models with Dipalitoyl Phosphatidylcholine IL,1990,33(4):465 and )-globulin.Proc Instn Mech Engrs,1998,21(2):Part 5 Sawae Y.Effect of Synovia Constituents on Friction and H,337 Effects of the Addition of La-Dipalmitoyl Phosphatidylcholine and y-globulin on the Lubricating Behavior of Hyaluronic Acid YU Luqing",LI Jiuqing",LU Yiqiang",ZHANG Be 1)Applied Science School,UST Beijing,Beijing 100083,China 2)Material Science and Engineering School,UST Beijing,Beijing 100083,China ABSTRACT A compound artificial synovia was prepared by adding La-dipalmitoyl phosphatidylcholine(L a-DPPC)riposomes and y globulin to a saline of sodium hyaluronate (HA),by which two kind of tribology slider pairs-PVA-H/PVA-H and PVA-H/316L S.S.were lubricated,an oscillator-type tri-biometer and M2000 wear test machine were used to determine their tribology parameters respectively.The experimental results showed that the lubricating behavior of compound synovia has a significantly improvement compared to the hyaluronic acid solution alone.It's probably that these improvements benefit from the adsorbed films on the PVA-H surface composed of protein and phospholipids and the boundary lubricating ability of the addi- tives. KEY WORDS artificial synovia;boundary lubrication;friction;wear一 122 - 北 京 科 技 大 学 学 报 200 1 年 第 2 期 P M卜-H /3 16 L 5 . .5 高载时的摩擦 因数小于低载时 的摩擦 因数 , PV A e H于V A气H高载 时的摩擦 因数 大于低载时的摩擦 因数 , 两者均属 于混合润滑 . (4 )卜球蛋 白和 L a 一O P P C 在高载荷 时可以 明显改善润滑性能 . 其 中 , L a - D P P C 的影响更为 显著 . (5 ) 相对 于 3 0% 小牛血 清 , Pv A -] 氏于V A , H 在复 合 人 工 滑 液 润 滑 下 , 磨 损 系 数 有 大 幅 度 的降低 , 最高 时降低 了 2 个数量级 , 达 到了 10 - `如m 3 . N( 一 , · m 一 ’ ) . 参 考 文 献 顾其胜 , 王 文斌 , 吴萍 . 医用透明质酸 钠在 临床中的 应用 综述 . 中国修复重 建外科杂志 , 19 98 , 12 (2) :5 珑 s w o hrt A , D o w s o n D , V厅lhg t V S om e 从w E v id e n e e on H um an J o int L u bir e at i o n . A n n R h e um D i s , 19 75 , 34 : 2 77 Ike u e h i K . T h e oR l e o f S y no v iia F l u id in J o i nt L u b r l e a￾t io n . i n : D . D心w s on et al . e d i t o sr . irT b o l o gy S e ir e s 3 0 , L u b - ir e at s an d L ub r i e iat o n E lse v i er S e i e n e e B V 1 9 9 5 . 65 M u r ak aj m i .T Tb e L u ibr e at i o n i n N at u ar l Sy n vo i a l oJ i n t s 即d J o int P or s th e s e s . J SM E Int e m a ti aon l J o unr a l , Sier e s 111 , 199 0 , 33 (4 ) : 4 6 5 S aw a e Y E fe e t o f S y n 0 v i a C o n st iut e nt s on F r i e ti o n an d W七ar o f U l tr a . h igh M o l e e u l ar W七i ght P o ly e hyt l en S liid gn A iga n s t P or s t h e ti e J o i nt M aet ir al s . W 七ar, 19 9 8 , 2 1 6 : 2 1 3 6 S aw ae 丫 M ur ak aj m i 工 E fe e t o f s e r u n O R o t e in s o n Fir e - ti o n an d w 七ar o f Por t h e ti e j o i nt M a t e r l a l s , P or e e e di n g s o f A S IAT RI B , 19 9 8 . 82 8 7 A h l r o o s T, S a认上o .v w七ar o f Por s th e ti e oj i nt M at e r i al s i n V时 i o u s L ub ir c a n t s , E l s e v i e .r W七叭 199 7 , 2 11 : 113 8 M u r ak a m i T, S即 w a e .Y hT e A d a Pti v e M u l tha o d e L u bir - e at i o n i n K力 e e P or s ht e s e s w iht A rt iif e ial C art i lag e D ur i gn 研厄 Iki n g . in : D . D o w s o n et a l . E d . E las t o hy dr o勿axn i e s , 96 E l s ve i e r S e i e cn e B V, 199 7 . 3 7 1 9 李久青 , 顾正秋 , 肖久梅 , 等 . 透明质酸 对人工关节材 料的润滑作用 . 北京科技 大学学报 , 2 0 0 , 22( 4) : 3 43 10 G u hz e lg qi u , X iao j ium e i , z h a n g X i an hg o ng . T h e D e v e l - 。 p m ent o f A rt i if e i a l A rt i e u lar C 别 rt l lag e 一 PV A 一 yH d r o g e l . B i o 一 m e d i e a l M at e r i al s an d E ng i n e ir ng, 1 99 8 , 8 : 75 1 杨抚华 . 医学 细胞 生物学概论 . 成都: 四 川科学技 术 出版社 , 19 8 5 . 24 12 M ur 公田 m i T, Hi g a ik H . A d atP ive M u lt im o de L u ibr e at i o n i n N川” r a l Sy n o v ial J o int s an d A rt iif e i a l OJ i lt s . R o e I n ost M e hc E n gr s , 19 9 8 , 2 1( 2 ) : P art H , 2 3 13 H i g山 H , Mu 扭汕叨1 .T hT e L u b r i c a tin g A b il iyt o f B i o - m e m b aner M o de l s iw ht D IP a liot y l P h o s Phat idy l e h o li n e an d 下-g l o b u lin . P r o e nI snt M e e h E n gr s , 19 98 , 2 1( 2) : P art H , 33 7 E fe c t s o f ht e A d d it i o n o f L a 一 D IP a lm it o y l P h o sP h at i勿l e h o li n e an d y 一 g l o b u li n o n ht e L ub ir e at i n g B e h va i o r o f H y a lur o n i e A e id YU L啊ign l气 LI iuJ q i心), L U狗 ia 心 ,) ZI 侧刀 G eB 尹 l ) A PPli e d S c i e n c e S e h o o l , U S T B e ij l n g , B e ij ing l 00 0 83 , hC ina Z) M at er ial S e i enc an d E ng in e e ir n g S c h o l , U S T B e ij in g , B e ij in g 10 0 0 8 3 , C h ian A B S T R A C T A e o m P o u n d art iif e i a l s y n o v i a w a s P r e P are d 勿 a d ign L a 一d iP a lm it oy l Pho s Ph a t i勿l e h o line (L 口- D P P C ) irP o s o m e s an d 卜g l o b u lin t o a s a lin e o f s o d i um 勿a lur o n at e ( H A ) , 妙 w hi hc wt o k i n d o f itr b o l o gy s lide r Pa i r s一 PV A e H于V A气H an d PV A刁刃3 1 6 L 5 . 5 . w e er lub ir e aet d , an o s e ill aot -r yt P e tr i e b i o m e t e r an d M 2 0 0 0 w e ar t e st m ac hi en w er u s e d ot d e t emr i n e het ir itr b o l o gy Par am e t e r s er sP e c t i v e .vl Th e e xP e d m e ant l er s u lt s s h o w e d t h a t het l u b ir e at ign b e h a v ior o f c o m Po u n d s y n o vi a ha s a s i脚if c a n t l y lm Por ve m e in e o m P ar e d t o ht e hy a l U丁o n i e ac id s o l iut o n a l o n e . ’tI s Pr o b ab ly t h a t het s e 而 Pr o v e m ent s b en e ift for m ht e ad s o br e d if ln s on th e PV A一H s ur fa e e e o m P o s e d o f Pr o t e i n an d Ph o sP h o liP id s an d t h e b o un da yr 1 u b r i e iat gn ab il iyt o f ht e ad d i - it v e s . K E Y WO R D S art iif e i a l sy n o v i a ; b o u n d a r y l u b r i e at i o n ; 示 ct ion ; w e ar