Classification of Natural Products Fatty acid-derived substances and polyketides More than 10,000 known Biosynthesized from simple acyl precursors such as acetyl CoA,propionyl CoA,and methylmalonyl CoA Natural products derived from fatty acids,such as prostaglandin E1,generally have most of the oxygen atoms removed Polyketides,such as the antibiotic erythromycin,often have many oxygen substituents remainingFatty acid-derived substances and polyketides ▪ More than 10,000 known ▪ Biosynthesized from simple acyl precursors such as acetyl CoA, propionyl CoA, and methylmalonyl CoA ▪ Natural products derived from fatty acids, such as prostaglandin E1 , generally have most of the oxygen atoms removed ▪ Polyketides, such as the antibiotic erythromycin, often have many oxygen substituents remaining Classification of Natural Products