Other Chiral Compounds Most chiral compound have at least one chiral(carbon)atom. However some molecules are chiral without having any asymmetric(carbon)atoms-their chirality is due to their shape. Conformational Enantiomerism occurs when certain molecules are so bulky or strained that they cannot easily convert from one chiral conformation to its mirror image conformation(the opposite of cis-1,2- dibromocyclohexane) Molecules can become locked'or stuck in one conformation which cannot equilibrate. This is more common for strained ring systems and/or bulky substituents. Ch05 Stereochemistry (landscape) Page 14Ch05 Stereochemistry (landscape) Page 14 Other Chiral Compounds Most chiral compound have at least one chiral (carbon) atom. However some molecules are chiral without having any asymmetric (carbon) atoms – their chirality is due to their shape. Conformational Enantiomerism occurs when certain molecules are so bulky or strained that they cannot easily convert from one chiral conformation to its mirror image conformation (the opposite of cis-1,2- dibromocyclohexane). Molecules can become ‘locked’ or stuck in one conformation which cannot equilibrate. This is more common for strained ring systems and /or bulky substituents. F2C CF2 F2C CF2 CF3 F2C CF2 F2C CF2 F3C (S) (R) I Br I Br X I Br I Br