Immunologic Theory: Lose control of immunologic balance Both cellular immunity and humoral immunity change 1) Macrophage↑- release l-1、IL6、TNF、EGF、 FGF etc.- stimulate t b lymphocyte proliferation and activation 2) Activity of killer cell (nK cell and T cell) 3)Produce anti-endometrium antibody 4) Abnormal expression of CAMs(cell adhesion molecules 2003-11-32003-11-3 7 Immunologic Theory： • Lose control of immunologic balance • Both cellular immunity and humoral immunity change. 1) Macrophage↑ release IL–1、IL–6、TNF、EGF、 FGF etc. stimulate T、B lymphocyte proliferation and activation 2) Activity of killer cell（NK cell and T cell）↓ 3) Produce anti–endometrium antibody 4) Abnormal expression of CAMs（cell adhesion molecules）