中国海洋药物 39卷 [37] LIN K H, LIN K C, LU W J, et al. Astaxanthin, a carotenoid, stim- [42] FAKHRI S, ABBASZADEH F, DARGAHI L, et al. Astaxanthin: a ulates immune responses by enhancing IFN-gamma and IL-2 secre mechanistic review on its biological activities and health benefits n in primary cultured lymphocytes in vitro and ex vio J. Int J Pharmacol Res, 2018. 136: 1 Mol Sci,2016,17(1):4452 [43 FASSETTRG, COOMBES JS Astaxanthin: a potential therapeutic [38] HAN J H, LEE Y S, IM J H, et al. Astaxanthin ameliorates lipopoly eent in cardiovascular disease J]. Mar Drugs, 2011, 93): 447-463 accharide-induced neuroinflammation, oxidative stress and memory [44] WANG J H, LIU S W, WANG H, et al. Xanthophyllomyces der dysfunction through inactivation of the signal transducer and activa- drorhous-derived astaxanthin regulates lipid metabolism and gut tor of transcription 3 pathway[J]. Mar Drugs, 2019, 17(2): 123-140 microbiota in obese mice induced by a high-fat diet[J]. Mar Drugs, [39] LI M Y, SUN L, NIU X T, et al. Astaxanthin protects lipopolys charide-induced inflammatory response in Channa argus through [45 KIM S J, CHANG H I Astaxanthin represses adipogenesis in 3T3- inhibiting NF-KB and MAPKs signaling pathways[J]. Fish Shellfish LI cells[J]. J Biotechnol, 2010, 150: 308-308 Immunol,2019,86:280-286 [46] CHOI H D, KIM J H, CHANG M J, et al. Effects of astaxanthin on [40] FARRUGGIA C, KIM M B, BAE M, et al. Astaxanthin exerts an- oxidative stress in overweight and obese adults). Phytother Res, inflammatory and antioxidant effects in macrophag pendent and independent manners[J]. J Nutr Biochem, 2018, 62: 147 MURAI T, KAWASUMI K, TOMINAGA K M. Effects of astaxan- 202-209. thin supplementation in healthy and obese dogs). vet Med(Auckl) [41] MIYACHI M, MATSUNO T, ASANO K, et al. Anti-inflammato- 2019,10:.29-35 ry effects of astaxanthin in the human gingival keratinocyte line48]左正宇,邵阳,刘杨,等.虾青素调节肝脂代谢与昼夜节律基因 NDUSD-lJJ. J Clin Biochem Nutr, 2015, 56(3): 171-178 表达食品科学,2019,403)165-172.88 中  国   海   洋   药   物 39 卷 [37] LIN K H, LIN K C, LU W J, et al. Astaxanthin, a carotenoid, stim￾ulates immune responses by enhancing IFN-gamma and IL-2 secre￾tion in primary cultured lymphocytes in vitro and ex vivo[J]. Int J Mol Sci, 2016, 17(1): 44-52. [38] HAN J H, LEE Y S, IM J H, et al. Astaxanthin ameliorates lipopoly￾saccharide-induced neuroinflammation, oxidative stress and memory dysfunction through inactivation of the signal transducer and activa￾tor of transcription 3 pathway[J]. Mar Drugs, 2019, 17(2): 123-140. [39] LI M Y, SUN L, NIU X T, et al. Astaxanthin protects lipopolysac￾charide-induced inflammatory response in Channa argus through inhibiting NF-κB and MAPKs signaling pathways[J]. Fish Shellfish Immunol, 2019, 86: 280-286. [40] FARRUGGIA C, KIM M B, BAE M, et al. Astaxanthin exerts an￾ti-inflammatory and antioxidant effects in macrophages in NRF2-de￾pendent and independent manners[J]. J Nutr Biochem, 2018, 62: 202-209. [41] MIYACHI M, MATSUNO T, ASANO K, et al. Anti-inflammato￾ry effects of astaxanthin in the human gingival keratinocyte line NDUSD-1[J]. J Clin Biochem Nutr, 2015, 56(3): 171-178. [42] FAKHRI S, ABBASZADEH F, DARGAHI L, et al. Astaxanthin: a mechanistic review on its biological activities and health benefits[J]. Pharmacol Res, 2018, 136: 1-20. [43] FASSETT R G, COOMBES J S. Astaxanthin: a potential therapeutic agent in cardiovascular disease[J]. Mar Drugs, 2011, 9(3): 447-465. [44] WANG J H, LIU S W, WANG H, et al. Xanthophyllomyces den￾drorhous-derived astaxanthin regulates lipid metabolism and gut microbiota in obese mice induced by a high-fat diet[J]. Mar Drugs, 2019, 17(6): 337-346. [45] KIM S J, CHANG H I. Astaxanthin represses adipogenesis in 3T3- L1 cells[J]. J Biotechnol, 2010, 150:308-308. [46] CHOI H D, KIM J H, CHANG M J, et al. Effects of astaxanthin on oxidative stress in overweight and obese adults[J]. Phytother Res, 2011, 25(12): 1813-1818. [47] MURAI T, KAWASUMI K, TOMINAGA K M. Effects of astaxan￾thin supplementation in healthy and obese dogs[J]. Vet Med (Auckl), 2019, 10: 29-35. [48] 左正宇 , 邵阳 , 刘杨 , 等 . 虾青素调节肝脂代谢与昼夜节律基因 表达 [J]. 食品科学 , 2019, 40(3): 165-172