Quantitative Pharmacokinetics To derive and use expressions for pharmacokinetic parameters,the first step is to establish a mathematical model that accurately relates the plasma drug concentration to the rates of drug absorption,distribution,and elimination.The one- compartment model is the simplest model of drug disposition,but the two-compartment model provides a more accurate representation of the pharmacokinetic behavior of many drugs.Quantitative Pharmacokinetics To derive and use expressions for pharmacokinetic parameters, the first step is to establish a mathematical model that accurately relates the plasma drug concentration to the rates of drug absorption, distribution, and elimination. The one￾compartment model is the simplest model of drug disposition, but the two-compartment model provides a more accurate representation of the pharmacokinetic behavior of many drugs