One-compartment model One-compartment model Ka Ke Absorption Drug- Elimination D A One-compartment model: V1=X1/Co V1:Apparent volume of distribution X1:Amount of drug in the compartment Co:Drug concentration at initial timeOne-compartment model: V1 = X1 / C0 V1: Apparent volume of distribution X1: Amount of drug in the compartment C0: Drug concentration at initial time One-compartment model