Two-compartment model Two-compartment model Blood Ka Ke Absorption Drug Elimination Kd Drug Tissues B Two-compartment model: Central compartment:Heart,lung,liver,kidney Peripheral compartment:Skin,muscle,fat tissue,etc. (1)Drug enters into the central compartment,(2)then distribute to peripheral compartment;(3)eventually,drug is eliminated from the central compartmentTwo-compartment model Two-compartment model: Central compartment: Heart, lung, liver, kidney Peripheral compartment: Skin, muscle, fat tissue, etc. (1) Drug enters into the central compartment, (2) then distribute to peripheral compartment; (3) eventually, drug is eliminated from the central compartment