Drug distribution Apparent volume of distribution Plasma (4L) ● Interstitial fluid (10L) Intracellular fluid (28L) B Calculation of the Va 50.00 (/6w) Distribution phase (a) 5.00 0.50 C Elimination phase(B) 0.05 0.00 0 Time 500mg injected IV Va Dose 500 mg Co 5 mg/L =100L C