BEH. 462/3.962J Molecular Principles of Biomaterials Spring 2003 C-N EDCNHS nDIT 分sH 5c-N~s⑥ (B-NH2Hydrazine -c-N⑥ &C-N-NHa 0(R-CHO i)NaBH3CN N^ SLinker-N⑧ Ns①}NHs Ns心Ma 3 N InkerS③ HOb NH-OH N-OH o EXample: targeting to vasculature Inflammatory signals delivered from peripheral tissues to endothelial cells induce upregulation of threat signals on the surface of these cells within the lumen of blood vessels o Cytokine signals such as IL-1B, TNF Chronic inflammation: upregulation of E-selectin Acute inflammation: upregulation of P-selectin o Used to direct neutrophils and monocytes to sites of inflammation Lecture 17-Drug targeting 4 of 7BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 o Example: targeting to vasculature ƒ Inflammatory signals delivered from peripheral tissues to endothelial cells induce upregulation of ‘threat’ signals on the surface of these cells within the lumen of blood vessels o Cytokine signals such as IL-1β, TNF • Chronic inflammation: upregulation of E-selectin • Acute inflammation: upregulation of P-selectin o Used to direct neutrophils and monocytes to sites of inflammation Lecture 17 – Drug targeting 4 of 7