An illustration of the chemical diversity Triterpene of sponge-derived molecules 气人 Sipholenol A 海绵化学结构类型 8 。A paCa设 人 and it 装水 aear Meroditerpene Ceramide鞘苷 selated from a marin evaluation showed that the meroditerpenes olated p2 dF人C,3e,43 5 135 An illustration of the chemical diversity of sponge-derived molecules H O O O H O Stellettin A (from South China Sea Jaspis Sp.) 异臭椿类三萜（Isomalabaricane triterpene）具 有很强的抗肿瘤及抗病毒等生理活性. 邓松之. 海洋臭椿类三萜的研究进展. 中国海洋药物，2004，23（1）：37-41. 三 萜 136 Triterpene Triterpene Four isomalabaricane triterpenoids were isolated from an extract of the sponge Rhabdastrella globostellata that was active in an assay measuring stabilization of the binding of DNA with DNA polymerase-b. This is the first report of natural products with the ability to promote stabilization of the DNA-polymerase covalent binary complex. J. Nat. Prod., 69 (3), 373 -376, 2006. H AcO O H O H HO O H HO O OH OH HO 137 Triterpenoids were isolated from the Red Sea sponge Callyspongia (=Siphonochalina) siphonella. Sipholane triterpenoids were evaluated for their cytotoxicity and effect on reversing P-glycoprotein-mediated MDR to colchicine. Sipholenol A was found to be the most potent, and it increased the sensitivity of resistant KB-C2 cells by 16 times toward colchicine (秋水 仙碱). This is the first report related to reversal of cancer chemotherapy resistance using these triterpenoids. J. Nat. Prod., 2007, 70 , 928 -931. Sipholenol Sipholenol A 138 海绵化学结构类型 Xestospongin C (Xestospongia sp. ) macrocyclic bis-oxaquinolizidine Jaspamide (Hemiastrella minor) macrocyclic lactam/lactone Alkaloids Peptide 139 A new meroditerpene, (+)-isojaspic acid has been isolated from a marine sponge Cacospongia. Bioactivity evaluation showed that the meroditerpenes isolated significantly inhibited Staphylococcus epidermidis. J. Nat. Prod., 70 (4), 628 -631, 2007 Meroditerpene 140 Ceramide Ceramide 鞘苷 Ectyoceramide is the first hexofuranosylceramide from the sponge Ectoplasia ferox. V. Costantino, et al. Eur. J. Org. Chem., 2003, 1433