Monoterpenoids in Red Algae Sesquiterpenoids in Red Algae 主买来源于凹顶LT 有 活性 which was C1s聚乙酰类代谢物 2.海绵Sponge C,聚乙联类新生物是红藻的一大类代谢产物，广泛存在 海纳动物门又称多孔动物门，为原始多细胞动物。没有 于凹顶藻属的多种红藻中，通常以魅状或环氧形式存在。 口，清化道，每言系绕。多孔，含一或多个内腔。 s mill 2.海绵Sponge 海绵化学结构类型 三 C Aplysinopsin Petrosia ficifom 44 129 Cl Br B Cl r Cl Halomon Cl Cl Br Cl Cl Br Cl Cl Cl Br Halogenated monoterpene is very popular in red algae. Especially Cl and Br often occur in monoterpenoids of red algae. Halomon, which was isolated from Portieria hornemannii, was regonized as an anti-cancer lead by NCI. Monoterpenoids Monoterpenoids in Red Algae in Red Algae 130 Sesquiterpenoids in Red Algae • 主要来源于凹顶藻属Laurencia OAc 1 HO Br CHBr2 OH 2 1 来源于澳大利亚Laurencia rigida,具有抗附着活性。 2 来源于未确定的Laurencia sp, 对乳腺癌和克隆癌有显著的活性。 J. Nat. Prod. 2001, 64, 690-791. 131 C15聚乙酰类代谢物 C15聚乙酰类衍生物是红藻的一大类代谢产物，广泛存在 于凹顶藻属的多种红藻中，通常以链状或环氧形式存在。 1 来源于土耳其海域红藻，具12元环醚结构。 2 来源于希腊海域红藻，具很强的杀蚂蚁活性。 Phytochemistry 2002, 59, 111-116 1 2 O O Cl Br Br H H O Br Cl AcO Cl 1 2 3 4 5 7 6 8 9 10 11 12 13 14 15 1 2 3 4 5 7 6 8 9 10 11 12 13 14 15 132 海绵动物门又称多孔动物门，为原始多细胞动物。没有 口，消化道，器官系统。多孔，含一或多个内腔。 2. 海 绵 Sponge Sponges are most primitive of the multicelled animals that have existed for 700–800 million years. 133 Petrosia ficiformis Petrosia ficiformis u Sponges are taxonomically grouped into 4 classes, 21 orders and 107 genuses with over approximately 15,000 species (ca 5000 occurred in our country). Sponge is about 1/15 of marine biomass. 2. 海 绵 Sponge 134 海绵化学结构类型 • 长链多烯，炔，醚，酰胺（多烯酮类）Polyketide • 吲哚生物碱类: Anticancer, Antivirus, Antibacterial • 大环内酯 • 甾体化合物 • 萜类化合物 • 肽化合物 O H2N OH Pachastrissamine O O OH O N H N N O NH Aplysinopsin Sponges are the rich source of novel secondary metabolites with diversities of biological activities Sesquiterpenoids Diterpenoids Sesterterpenoids Triterpenoids (few) Structural Diversity