口服可吸收的Lipinski类药5原则(RO5) 口服药物： ·MW<=500 ·clogP<=5 ·H donors<=5 ·H acceptors<=10 90%的药最多违背一项 Extension: 5.Rotable Bonds <=10 6.PSA<=140 Eg.PSA<=120(被动扩散)；PSA=60~70 for CNS(to cross BBB口服可吸收的Lipinski类药5原则(RO5) 口服药物： • MW <= 500 • clogP <= 5 • H donors <= 5 • H acceptors <= 10 90%的药最多违背一项 Extension: 5. Rotable Bonds <= 10 6. PSA <= 140 Eg. PSA <= 120 (被动扩散）； PSA = 60~70 for CNS (to cross BBB