Common features of acute leukemias ALL +AML ■ Clinical features 1. Abrupt stormy onset--within 3 months 2. Symptoms related to depression of normal marrow function Pathophysiology Block in differentiation blasts accumulate in marrow normal hematopoietic stem cells Anemia Mature leukocytes Thrombocytopenia fatigue infection bleedingCommon features of acute leukemias ALL +AML ◼ Clinical features 1. Abrupt stormy onset—within 3 months 2. Symptoms related to depression of normal marrow function Pathophysiology Block in differentiation blasts accumulate in marrow normal hematopoietic stem cells Anemia fatigue Mature leukocytes infection Thromobocytopenia bleeding