NORMAL CELL REVERSIBLE (homeostasis) INJURY Stress Injurious Mi以， stimulus transient ADAPTATION CELL INJURY Inability to adapt Severe, progressive IRREVERSIBLE INJURY CELL NE CROSIS DEATH APOPTOSIS Cell injury results when cells are stressed so severely that they are no longer able to adapt or when cells are exposed to inherently damaging agents or suffer from intrinsic abnormalities. Injury may progress through a reversible stage and culminate in cell death. Cell injury results when cells are stressed so severely that they are no longer able to adapt or when cells are exposed to inherently damaging agents or suffer from intrinsic abnormalities. Injury may progress through a reversible stage and culminate in cell death