Acid-Base Reaction to Form Enolate Very strong base is required for complete reaction.Example: CH3 CH3 CH3-CH CH3-CH N一H CaH Li C.Hio N: Li计 CH-CH n-butyllithium butane CH3一CH CH, CH; diisopropylamine lithium diisopropylamide (LDA) Copyright 2005 Pearson Prentice Hall,Inc. (i-CH)2N-Li+ (i-C2H)2N-H cyclohexanone LDA lithium enolate (pK,=36 (pK.=19) of cyclohexanone (100%) Copyright 2005 Pearson Prentice Hall,Inc. Acid-Base Reaction to Form Enolate Very strong base is required for complete reaction. Example: