Methods results Extracellular Injurious agen What happens after their int 00000n Mitochon Smooth ER coexpressing the NRI/NR Increased cytosolic Ca constitutively active DAPK Activation of DAPKI WDAPKI cellular enzymes D DAPKI activation Protease Endo- ATPase t mite nuclease transition channel conductance ↓ Phospho- Disruption DAMAGE DAMAGE ↓ATP Figure I-17 Sources and consequences of increased cytosolic calcium Figure 3. Robbins BASIC PATHOLOGY, 9th Edition in cell injury. ATP, adenosine triphosphate, ATPase, adenosineMethods & Results What happens after their interaction?  coexpressing the NR1/NR2B receptors with a constitutively active DAPK1 (cDAPK1), or the wild-type DAPK1 (wDAPK1)  DAPK1 activation increased the NR1/NR2B Ca2+ channel conductance Figure 3. Robbins BASIC PATHOLOGY, 9th Edition