Methods results How does the daPI interact with nr2B2 generating a series of NMDA receptor NR2B C-terminal deletion mutants only the NR2B 292- 1304 fragment capable of binding with DAPKI(using a specific motif) coexpressing CDAPKI with the normal NRI/NR2B or the mutant NRI/NR2B $303 A receptors(a Ser-1303 residue replaced with an Ala) CDAPKI increased the peak amplitude of the recombinant NRT/NR2B receptor currents, but nof the mutant receptorMethods & Results How does the DAPK1 interact with NR2B?  generating a series of NMDA receptor NR2B C-terminal deletion mutants  only the NR2B1292-1304 fragment capable of binding with DAPK1 (using a specific motif)  coexpressingcDAPK1 with the normal NR1/NR2B or the mutant NR1/NR2B S1303 A receptors (a Ser-1303 residue replaced with an Ala)  cDAPK1 increased the peak amplitude of the recombinant NR1/NR2B receptor currents, but not the mutant receptor