中国疼痛医学杂志 Chinese journal of pain medicine201319(5) [9 Scherrer G, Imamachi N, Cao YQ, et al. Dissociation [21] Sakurada T, Mizoguchi H, Kuwahata H, et al of the opioid receptor mechanisms that control mecha- Intraplantar injection of bergamot essential oil induces nical and heat pain. Cell, 2009, 137: 1148-1159 peripheral antinociception mediated by opioid [10] Persson T, Calafat J, Janssen H, et al. Specific granul chanism. Pharmacol Biochem Behav. 2011. 97 of human eosinophils have lysosomal characteristics presence of lysosome-associated membrane proteins [22] He L, Kim J, Ou C, et al. Methadone antinociception and acidification upon cellular activation. Biochem is dependent on peripheral opioid receptors. J Pain, Biophys Res Commun, 2002, 291: 844-854 2009,10:369~379 Il] Przewlocki R, Przewlcka B Opioids in chronic pain. [23] Al-Khrasani M, Spetea M, Friedmann T et al Eur J Pharmacol. 2001. 429: 1-3 DAMGO and 6 B-glycine substituted 14-0- [12] Craft RM, Mogil JS, Aloisi AM. Sex differences in methyloxymorphone but not morphine show pain and analgesia: the role of gonadal hormones peripheral, preemptive antinociception after systemic Eur j Pain,2004,8:397~411 administration in a mouse visceral pain model and [13] Gear RW, Miaskowski C, Gordon NC, et al. Kappa gh intrinsic efficacy in the isolated rat vas deferens opioids produce significantly greater analgesia in Brain Res Bull. 2007. 74: 369-375 women than in men. Nat Med, 1996, 2: 1248-1250 [24] Al-Khrasani M, Lacko E, Riba P, et al. The central [14] Auh Qs, Ro JY. Effects of peripheral k opioid versus peripheral antinociceptive effects of u-opioid receptor activation on inflammatory mechanical receptor agonists in the new model of rat visceral hyperalgesia in male and female rats. Neurosci Lett, ain. BrainBrain Res bull. 2012.87: 238-243 2012,524:l1l-115 [25] Takasuna M, Negus Ss, DeCosta BR, et al. Opioid [15] Berg KA, Rowan MP, Sanchez TA, et al. Regulati pharmacology of the antinociceptive effects of of K-opioid receptor signaling in peripheral sensory loperamide in mice. Behav Pharmacol, 1994, 5: 189 neurons in vitro and in vivo. J Pharmacol Exp Ther 195 2011,33892-99 [26] Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic [16] Cunha TM, Souza GR, Domingues AC, et al effects of loperamide in a model of rat neuropathic Stimulation of peripheral kappa opioid recepto ain are mediated by peripheral delta-opioid receptors inhibits inflammatory hyperalgesia via activation of Neurosci Lett, 2007, 411: 143-146 the P13k y /AKT/nNOS/NO signaling pathway. Mol [27] Correa JD, Paiva-Lima P, Rezende rm, et al. Peripheral Pain,2012,8:10 receptors mediate the hypoalgesic effect of celecoxib [17 Pacheco DF, Pacheco CM, Duarte ID. Peripheral in a rat model of thermal hyperalgesia. Life Sci, 2010 antinociception induced by 8-opioid receptors 86951~956 activation, but not W-or K-, is mediated by Ca2+- [28 Mousa SA, Shakibaei M, Sitte N, et al. Subcellular activated CI- channels. Eur j Pharmacol. 2012 pathways of beta-endorphin synthesis, processing, 674:255~259 and release from immunocytes inflammatory pain 18]巩仔鹏.从β-内啡肽的表达探讨华蟾素治疗癌 Endocrinology.,2004,145:131-1341 痛的外周机制研究.三峡大学硕士研究生论文, [29 Romero TR, Guzzo Ls, Duarte ID, et al. Mu, delta 20l1 and kappa opioid receptor agonists induce peripheral !余学琴.局部给予华蟾素对H22足部荷瘤小鼠癌 antinociception by activation of endogenous norad 痛行为的影响及其外周机制研究.三峡大学硕士 energic system. J Neurosci Res, 2012, 90: 1654 研究生论文,2012 l661 [20] Guzzo ls, Perez ac, Romero tr,etal, Cafestol,[30李小梅,董艳娟,赵雩卿,等.神经病理性疼 a coffee-specific diterpene, induces peripheral 痛外周阿片受体研究进展.中国疼痛医学杂志, antinociception mediated by endogenous opioid 2011.17:466 peptides. Clin Exp Pharmacol Physiol, 2012, 39: 412 ~416 91994-2013ChinaAcademicJournalElectronicPublishingHouse.Allrightsreservedhttp://www.cnki.net· 292 · 中国疼痛医学杂志 Chinese Journal of Pain Medicine 2013,19,(5) 中国疼痛医学杂志 Chinese Journal of Pain Medicine 2013,19,(5) [9] Scherrer G, Imamachi N, Cao YQ, et al. Dissociation of the opioid receptor mechanismsthat control mecha￾nical and heat pain. Cell, 2009, 137:1148 ~ 1159. [10] Persson T, CalafatJ,Janssen H, et al. Specific granules of human eosinophils have lysosomal characteristics: presence of lysosome-associated membrane proteins and acidification upon cellular activation. Biochem Biophys Res Commun, 2002, 291:844 ~ 854. [11] Przewlocki R, Przewlcka B. Opioids in chronic pain. EurJ Pharmacol, 2001, 429:1 ~ 3. [12] Craft RM, Mogil JS, Aloisi AM. Sex differences in pain and analgesia : the role of gonadal hormones. EurJ Pain , 2004, 8:397 ~ 411. [13] Gear RW, Miaskowski C, Gordon NC, et al. Kappa￾opioids produce significantly greater analgesia in women than in men. Nat Med, 1996, 2:1248 ~ 1250. [14] Auh QS, Ro JY. Effects of peripheral κ opioid receptor activation on inflammatory mechanical hyperalgesia in male and female rats. Neurosci Lett, 2012, 524:111 ~ 115. [15] Berg KA, Rowan MP, Sanchez TA, et al. Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo. J Pharmacol Exp Ther, 2011, 338:92 ~ 99. [16] Cunha TM, Souza GR, Domingues AC, et al. Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway. Mol Pain, 2012, 8:10. [17] Pacheco DF, Pacheco CM, Duarte ID. Peripheral antinociception induced by δ-opioid receptors activation, but not μ- or κ-, is mediated by Ca2+- activated Cl- channels. Eur J Pharmacol, 2012, 674:255 ~ 259. [18] 巩仔鹏 . 从 β- 内啡肽的表达探讨华蟾素治疗癌 痛的外周机制研究 . 三峡大学硕士研究生论文， 2011. [19] 余学琴 . 局部给予华蟾素对 H22 足部荷瘤小鼠癌 痛行为的影响及其外周机制研究 . 三峡大学硕士 研究生论文，2012. [20] Guzzo LS, Perez AC, Romero TR, et al., Cafestol, a coffee-specific diterpene, induces peripheral antinociception mediated by endogenous opioid peptides. Clin Exp Pharmacol Physiol, 2012, 39:412 ~ 416. [21] Sakurada T, Mizoguchi H, Kuwahata H，et al. Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism. Pharmacol Biochem Behav, 2011, 97: 436 ~ 443. [22] He L, Kim J, Ou C, et al. Methadone antinociception is dependent on peripheral opioid receptors. J Pain, 2009, 10:369 ~ 379. [23]Al-Khrasani M, Spetea M, Friedmann T. et al. DAMGO and 6β-glycine substituted 14-O￾methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens. Brain Res Bull, 2007, 74:369 ~ 375. [24] Al-Khrasani M, Lackó E, Riba P, et al. The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain. Brain Brain Res Bull, 2012, 87:238 ~ 243. [25] Takasuna M, Negus SS, DeCosta BR, et al. Opioid pharmacology of the antinociceptive effects of loperamide in mice. Behav Pharmacol, 1994, 5:189 ~ 195. [26] Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neurosci Lett, 2007, 411:143 ~ 146. [27] Correa JD, Paiva-Lima P, Rezende RM, et al. Peripheral receptors mediate the hypoalgesic effect of celecoxib in a rat model of thermal hyperalgesia. Life Sci, 2010, 86:951 ~ 956. [28] Mousa SA, Shakibaei M, Sitte N, et al. Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes inflammatory pain. Endocrinology, 2004, 145:1331 ~ 1341. [29] Romero TR, Guzzo LS, Duarte ID, et al. Mu, delta, and kappa opioid receptor agonists induce peripheral antinociception by activation of endogenous noradr￾energic system. J Neurosci Res, 2012, 90:1654 ~ 1661. [30] 李小梅，董艳娟，赵雩卿，等 . 神经病理性疼 痛外周阿片受体研究进展 . 中国疼痛医学杂志 , 2011, 17: 466