生理学报 Acta Physiologica Sinica, October25,2017,695):677-684 sory neurons promotes the development of infammatory rat prelimbic medial prefrontal cortex to control anxiety-like heat hyperalgesia in rats. Sci Signal 2014; 7(331): ra61 behavior. Neuropharmacology 2012; 63(2): 202-210 36 Bandelow B. Generalized anxiety disorder and pain. Mod 44 Rubino T, Realini N, Castiglioni C, Guidali C, Vigano D, Trends Pharmacopsychiatry 2015: 30: 153-165 Marras e. Petrosino S. Perletti G. Maccarrone M. Di Marzo 37 Li JX. Pain and depression comorbidity: a preclinical V, Parolaro D. Role in anxiety behavior of the endocannabi- perspective. Behav Brain Res 2015: 276: 92-98 noid system in the prefrontal cortex. Cereb Cortex 2008 38 Wang GQ, Cen C, Li C, Cao S, Wang N, Zhou Z, Liu XM 18(6):1292-1301 Xu Y, Tian NX, Zhang Y, Wang J, Wang LP, Wang Y. Deacti- 45 Fattori V, Hohmann MS, Rossaneis AC, Pinho-Ribeiro FA vation of excitatory neurons in the prelimbic cortex via Caks Verri WA. Capsaicin: Current understanding of its mecha- promotes pain sensation and anxiety. Nat Commun 2015:6: nisms and therapy of pain and other pre-clinical and clinical 7660 uses Molecules 2016, 21(7). pii: E844 39 Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim 46 Gill CH, Randall A, Bates SA, Hill K, Owen D, Larkma T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge PM, Caims W, Yusaf SP, Murdock PR, Strijbos PJ, Powel GL. Zhuo M. Coexistence of two forms of ltP in ACc AJ. Benham CD. Davies CH. Characterization of the human provides a synaptic mechanism for the interactions between HCNI channel and its inhibition by capsazepine. Br J Phar- anxiety and chronic pain. Neuron 2015: 85(2): 377-389 macol2004;14303):411-42l 40 Lee M, Manders TR, Eberle SE, Su C, D'amour J, Yang R, 47 Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S Lin HY, Deisseroth K, Froemke RC, Wang J. Activation of Capsazepine is a novel activator of the delta subunit of the corticostriatal circuitry relieves chronic neuropathic pain. J human epithelial Na channel. J Biol Chem 2004: 279(43) Neurosci2015;35(13):5247-5259 44483-4 41 de Novelli v, Vita D, Gatta L, Luongo L, Bellini G, De 48 Zuo GF, Li MH, Zhang JX, Li B, wang ZM, Wang Q, Xiao H, Chiaro M, Marabese 1, Siniscalco D, Boccella S, Piscitelli F Chen SL. Capsazepine concentration dependently inhibits Di Marzo V palazzo E. Rossi F. Maione S. The blockade of currents in HEK 293 cells mediated by human hyperpolar the transient receptor potential vanilloid type I and fatty acid ization-activated cyclic nucleotide-gated 2 and 4 channels amide hydrolase decreases symptoms and central sequelae in Exp Biol Med 2013: 238(9): 1055-1061 the medial prefrontal cortex of neuropathic rats. Mol Pain 49 Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang 20l1:7:7 SU, Suh YG, Blumberg PM, Lee J High affinity antagonists 42 Aguiar DC, Terzian AL, Guimaraes FS, Moreira FA. Anxio of the vanilloid receptor. Mol Pharmacol 2002: 62(4): 94 lytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPVI) channels in the medial 50 Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, prefrontal cortex of rats. Psychopharmacology(Berl) 2009 ee J, Kang SU, Lim JO, Lee J. High-affinity partial ago- 205(2):217-225 nists of the vanilloid receptor. Mol Pharmacol 2003; 64(2) 43 Fogaca MV, Aguiar DC, Moreira FA, Guimaraes FS. The 325-333 endocannabinoid and endovanilloid systems interact in the684 生理学报 Acta Physiologica Sinica, October 25, 2017, 69(5): 677–684 sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal 2014; 7(331): ra61. 36 Bandelow B. Generalized anxiety disorder and pain. Mod Trends Pharmacopsychiatry 2015; 30: 153–165. 37 Li JX. Pain and depression comorbidity: a preclinical perspective. Behav Brain Res 2015; 276: 92–98. 38 Wang GQ, Cen C, Li C, Cao S, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LP, Wang Y. Deacti￾vation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun 2015; 6: 7660. 39 Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M. Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron 2015; 85(2): 377–389. 40 Lee M, Manders TR, Eberle SE, Su C, D'amour J, Yang R, Lin HY, Deisseroth K, Froemke RC, Wang J. Activation of corticostriatal circuitry relieves chronic neuropathic pain. J Neurosci 2015; 35(13): 5247–5259. 41 de Novellis V, Vita D, Gatta L, Luongo L, Bellini G, De Chiaro M, Marabese I, Siniscalco D, Boccella S, Piscitelli F, Di Marzo V, Palazzo E, Rossi F, Maione S. The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats. Mol Pain 2011; 7: 7. 42 Aguiar DC, Terzian AL, Guimarães FS, Moreira FA. Anxio￾lytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats. Psychopharmacology (Berl) 2009; 205(2): 217–225. 43 Fogaça MV, Aguiar DC, Moreira FA, Guimarães FS. The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior. Neuropharmacology 2012; 63(2): 202–210. 44 Rubino T, Realini N, Castiglioni C, Guidali C, Viganó D, Marras E, Petrosino S, Perletti G, Maccarrone M, Di Marzo V, Parolaro D. Role in anxiety behavior of the endocannabi￾noid system in the prefrontal cortex. Cereb Cortex 2008; 18(6): 1292–1301. 45 Fattori V, Hohmann MS, Rossaneis AC, Pinho-Ribeiro FA, Verri WA. Capsaicin: Current understanding of its mecha￾nisms and therapy of pain and other pre-clinical and clinical uses. Molecules 2016; 21(7). pii: E844. 46 Gill CH, Randall A, Bates SA, Hill K, Owen D, Larkman PM, Cairns W, Yusaf SP, Murdock PR, Strijbos PJ, Powell AJ, Benham CD, Davies CH. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Phar￾macol 2004; 143(3): 411–421. 47 Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel. J Biol Chem 2004; 279(43): 44483–44489. 48 Zuo GF, Li MH, Zhang JX, Li B, Wang ZM, Wang Q, Xiao H, Chen SL. Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolar￾ization-activated cyclic nucleotide-gated 2 and 4 channels. Exp Biol Med 2013; 238(9): 1055–1061. 49 Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J. High affinity antagonists of the vanilloid receptor. Mol Pharmacol 2002; 62(4): 947– 956. 50 Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J. High-affinity partial ago￾nists of the vanilloid receptor. Mol Pharmacol 2003; 64(2): 325–333