1/26/2016 The History of Chemotherapy The History of Chemotherapy ·8ec8ee8￥Y .1928:Fleming discovered penicillin, Ehrlich,Germany produced by Penicillium ·be8 oul e 1932:Prontosil red dye used for streptococcal infections horr pathager but 1940:First clinical trials of penicillin Father of chemotherapy Today there is a growing problem of antibiotic resistance %gea25米t "One sometimes finds what one is ·Nobel prize in1908 ot looking for." Alexander Fleming TABLE 20.7 Representative Sources of Antibiotics cieifn8m5mbncsie2alteiera Microorganism Antibiotic GRAM-POSITIVE RODS Most commonly Streptomyces species B联nan Polymyrin ACTINOMYCETES FUNGI 1/26/2016 2 The History of Chemotherapy • Birth of modern chemotherapy is credited to the efforts of Paul Ehrlich, Germany • He speculated about a “magic bullet” that would selectively target and destroy pathogens but not harm the host. • Father of chemotherapy • Made the first magic bullet Salvarsan to treat syphilis • Nobel prize in 1908 The History of Chemotherapy • 1928: Fleming discovered penicillin, produced by Penicillium • 1932: P t sil d d s d f 1932: Prontosil red dye used for streptococcal infections • 1940: First clinical trials of penicillin • Today there is a growing problem of antibiotic resistance Microbes from natural environments (soil) will show bacterial inhibition by antibiotics produced by bacteria Most commonly Streptomyces species