I.DNA Microarray DNA microarray results A Novel Inhibitor of the NF-KB Signaling Pathway Encoded by the Parapoxvirus Orf Viru TABLE 1 Summary of NF-KB-regulated gene s de ted by oarray and real-time PCR in primary OFTu cells infected with OV-1A82 or ORFV024 deletion mutant virus OV-IA82A024 mRNA expres: Gene Description GenBank Microa ethOV-LAS20R 4hp.i CCL20 Chemokine ligant 20 NM17426380.02 205.16 CXCL1 Chemokine ligant 1 7M175700 73.72 CXCL2 Chemokine ligant 2 NnM17429969.95 CXCL3 Chemokine ligant3 NM001046513727 12.34 ICAM1 Intercellular adhesion molecule(CD54) 7M174348 3.29 3.29 IL-1a IL-1a NM174092 70.09 1.05 L-6 L-6 7M173923 3.09 8.97 L-8 L-8 NM173925 10.98 11.46 IRF1/LOC789216 IFN regulatory factor 1 7M177432 17.01 1.00 L0C614198 Similar to T-cell activation NF-KB like protein(TA-NF-KB) X0M865597 723 1.00 MAIL Molecule possessing ankyrin repeats induced by LPS 1M17472615.09 2.05 MGC142340 Similar to pentraxin-related protein PTX3 precursor M0010762595.98 752 MMP1 Matrix metallopeptidase 1 (intersticial collagenase) NM1741123.01 4.91 MMP13 Matrix metallopeptidase 13(collagenase 3) NM174398 1.70 2.88 MMP3 Matrix metallopeptidase 3(progelatinase) XM586521 2.08 292 NFKBIA Nuclear factor of kappa light polypeptidase gene enhancer in B-cell inhibitor.alpha NM_0010458689.12 4.40 PTGS2 Prostaglandin-endoperoxidase synthase 2 NM17445 936 3.73 .-a Fold changes are relative to OFTu cells infected the wild-type virus OV-IA82 Fold chan relative to mock-infected OFTu cells and the expression levels on those cells were equal to 1.Values are expressed as calculated based on the mean express P<0.05:t,P<0.01 DNA microarray results I. DNA Microarray