安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Drug Toxicity and Adverse Drug Reactions Chapter:16 Teacher's name:Qiong Huang Grade:2013 Department:Clinical Medicine,School of International Education Time:14:30-16:50 Date(D/M/Y):3/16/2016 Lecture Notes: [MODULES] 2min MODULE 1:Introduction to adverse drug reaction MODULE 2:The classification of adverse drug reactions MODULE 3:The mechanism of drug toxicity MODULE 4:The contexts of drug toxicity MODULE 5:Questions and discussions JINTRODUCTION TO ADVERSE DRUG REACTION] 3min 1.ADVERSE DRUG REACTION (ADR):a response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis,diagnosis,or therapy of disease or for the modification of physiologic function. Side effects-minor unwanted effects of drugs Adverse Reaction-serious effects of drugs at therapeutic doses Toxicity-adverse drug event that occurs at high dose 2.IMPACT OF ADVERSE DRUG REACTIONS [THE CLASSIFICATION OF ADVERSE DRUG REACTIONS] 10min 1.Type A:Augmented pharmacologic effects dose dependent and predictable responsible for at least two-thirds of ADRs common,low mortality related to a pharmacological action of the drug 2.Type B:Bizarre effects dose independent and unpredictable uncommon,high mortality not related to a pharmacological action of the drug 3.Type C:Chronic effects dose-related and time-related associated with long-term use uncommon,involves dose accumulation 4.Type D:Delayed effects ·time-related uncommon,usually dose-related occurs or becomes apparent some time after the use of the drug 5.Type E:End-of-treatment effects 3安徽医科大学国际教育学院教案与讲稿 3 Teaching Plan for International Students, AHMU Title of the course: Drug Toxicity and Adverse Drug Reactions Chapter: 16 Teacher’s name: Qiong Huang Grade: 2013 Department: Clinical Medicine, School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/16/2016 Lecture Notes: [MODULES] 2min MODULE 1: Introduction to adverse drug reaction MODULE 2: The classification of adverse drug reactions MODULE 3: The mechanism of drug toxicity MODULE 4: The contexts of drug toxicity MODULE 5: Questions and discussions [INTRODUCTION TO ADVERSE DRUG REACTION] 3min 1. ADVERSE DRUG REACTION (ADR): a response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease or for the modification of physiologic function.
Side effects – minor unwanted effects of drugs
Adverse Reaction – serious effects of drugs at therapeutic doses
Toxicity – adverse drug event that occurs at high dose 2. IMPACT OF ADVERSE DRUG REACTIONS [THE CLASSIFICATION OF ADVERSE DRUG REACTIONS] 10min 1. Type A: Augmented pharmacologic effects
dose dependent and predictable
responsible for at least two-thirds of ADRs
common, low mortality
related to a pharmacological action of the drug 2. Type B: Bizarre effects
dose independent and unpredictable
uncommon, high mortality
not related to a pharmacological action of the drug 3. Type C: Chronic effects
dose-related and time-related
associated with long-term use
uncommon, involves dose accumulation 4. Type D: Delayed effects
time-related
uncommon, usually dose-related
occurs or becomes apparent some time after the use of the drug 5. Type E: End-of-treatment effects