安微医科大学国际教育学院教案与讲稿 ●uncommon occurs soon after withdrawal of the drug 6.Type F:Failure of therapy common,dose-related unexpected failure of therapy often caused by drug interactions [THE MECHANISM OF DRUG TOXICITY] 18min 1."On-target"adverse effects:which are the result of the drug binding to its intended receptor, but at an inappropriate concentration,with suboptimal kinetics,or in the incorrect tissue niened urnengod X ·Dose too high 2."Off-target"adverse effects:which are caused by the drug binding to a target or receptor for which it was not intended 3.Production of toxic metabolites 95% glucuronidation total excreted acetaminophen and sulfation metabolites 5% OVERDOSE CYP450 ymesN-acetyl-benzoquinoneimine glutathione reacts with nucleophilic groups on Fulminant hepatotoxicity proteins to produce covalent protein and death derivatives 4. Production of harmful immune responses Type I hypersensitivity response(immediate hypersensitivity) Type II hypersensitivity response(antibody-dependent cytotoxic hypersensitivity) 。 Type IlI hypersensitivity response(immune complexmediated hypersensitivity) Type IV hypersensitivity response(delayed-type hypersensitivity) 5.Idiosyncratic responses ·rare adverse effects individual genetic differences in the response to the drug molecule 。difficult to predict [THE CONTEXTS OF DRUG TOXICITY] 4min 4安徽医科大学国际教育学院教案与讲稿 4
uncommon
occurs soon after withdrawal of the drug 6. Type F: Failure of therapy
common, dose-related
unexpected failure of therapy
often caused by drug interactions [THE MECHANISM OF DRUG TOXICITY] 18min 1. “On-target” adverse effects: which are the result of the drug binding to its intended receptor, but at an inappropriate concentration, with suboptimal kinetics, or in the incorrect tissue 2. “Off-target” adverse effects: which are caused by the drug binding to a target or receptor for which it was not intended 3. Production of toxic metabolites 4. Production of harmful immune responses
Type I hypersensitivity response (immediate hypersensitivity)
Type II hypersensitivity response (antibody-dependent cytotoxic hypersensitivity)
Type III hypersensitivity response (immune complexmediated hypersensitivity)
Type IV hypersensitivity response (delayed-type hypersensitivity) 5. Idiosyncratic responses
rare adverse effects
individual genetic differences in the response to the drug molecule
difficult to predict [THE CONTEXTS OF DRUG TOXICITY] 4min