References Di Lullo, G. A, Sweeney, S. M, Korkko, J, Ala-Kokko, L& San Antonio, J D. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem 277, 4223-31(2002) Lemire, J M, Merrilees, M.J., Braun, K.R.& Wight, T N. Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. J Cell Physio/ 190, 38-45 (2002 3. Hubbell, J A, Massia, S P& Drumheller, P. D. Surface-grafted cell-binding peptides in tissue engineering of the vascular graft. Ann N Y Acad Sci 665, 253-8(1992) Drumheller, P D. Hubbell, J. A. Polymer networks with grafted cell adhesion peptides for highly biospecific cell adhesive substrates. Anal Biochem 222, 380-8(1994) Kuhl, P. R.& Griffith-Cima, L G. Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase. Nat Med 2, 1022-7(1996) Cook, A.D. et al. Characterization and development of RGD-peptide-modified poly (lactic acid-co-lysine) as an interactive, resorbable biomaterial. J Biomed Mater Res 35, 513-23(1997) Mann, B K, Schmedlen, R H.& West, J. L. Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 22, 439-44(2001) le Gennes, P G Conformations of polymers attached to an interface Macromolecules 13, 1069-1075 (1980) 9. Milner, S T Polymer brushes. Science 251, 905-914(1991) Mendelsohn, J. D, Yang, S.Y., Hiller, J, Hochbaum, A. L& Rubner, M. F. Rational design of cytophilic and cytophobic polyelectrolyte multilayer thin films. Biomacromolecules 4, 96-106(2003) 11. Banerjee, P, Irvine, D. J, Mayes, A M.& Griffith, L. G. Polymer latexes for cell-resistant and cell-interactive surfaces. J Biomed Mater Res 50, 331-9.(2000) 13 QineD J, Mayes, A M& Griffith, L G Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Irvine,D,de Synthesis and Characterization of Comb Thin Films. Biomacromol. 2, 85-94(2001) properties. J Biomed Mater Res 40, 498-509.(1998) 14. Irvine, D. J, Ruzette, A. V, Mayes, A. M.& Griffith, L. G. Nanoscale clustering of RGD peptides at surfaces using comb polymers. 2. Surface segregation of comb polymers in polylactide Biomacromolecules 2, 545-56(2001) 15. Patel, N et al. Spatially controlled cell engineering on biodegradable polymer surfaces. Faseb Journa/ 12, 1447 1454(1998 16. Palecek, S. P, Loftus, J C, Ginsberg, M. H, Lauffenburger, D. A& Horwitz, A. F. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness Nature 385, 537-40 (1997) Lecture 3- Biological Recognition 15 of 15References 1. Di Lullo, G. A., Sweeney, S. M., Korkko, J., Ala-Kokko, L. & San Antonio, J. D. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem 277, 4223-31 (2002). 2. Lemire, J. M., Merrilees, M. J., Braun, K. R. & Wight, T. N. Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. J Cell Physiol 190, 38-45 (2002). 3. Hubbell, J. A., Massia, S. P. & Drumheller, P. D. Surface-grafted cell-binding peptides in tissue engineering of the vascular graft. Ann N Y Acad Sci 665, 253-8 (1992). 4. Drumheller, P. D. & Hubbell, J. A. Polymer networks with grafted cell adhesion peptides for highly biospecific cell adhesive substrates. Anal Biochem 222, 380-8 (1994). 5. Kuhl, P. R. & Griffith-Cima, L. G. Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase. Nat Med 2, 1022-7 (1996). 6. Cook, A. D. et al. Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial. J Biomed Mater Res 35, 513-23 (1997). 7. Mann, B. K., Schmedlen, R. H. & West, J. L. Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 22, 439-44 (2001). 8. de Gennes, P. G. Conformations of polymers attached to an interface. Macromolecules 13, 1069-1075 (1980). 9. Milner, S. T. Polymer brushes. Science 251, 905-914 (1991). 10. Mendelsohn, J. D., Yang, S. Y., Hiller, J., Hochbaum, A. I. & Rubner, M. F. Rational design of cytophilic and cytophobic polyelectrolyte multilayer thin films. Biomacromolecules 4, 96-106 (2003). 11. Banerjee, P., Irvine, D. J., Mayes, A. M. & Griffith, L. G. Polymer latexes for cell-resistant and cell-interactive surfaces. J Biomed Mater Res 50, 331-9. (2000). 12. Irvine, D. J., Mayes, A. M. & Griffith, L. G. Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 1. Synthesis and Characterization of Comb Thin Films. Biomacromol. 2, 85-94 (2001). 13. Irvine, D. J. et al. Comparison of tethered star and linear poly(ethylene oxide) for control of biomaterials surface properties. J Biomed Mater Res 40, 498-509. (1998). 14. Irvine, D. J., Ruzette, A. V., Mayes, A. M. & Griffith, L. G. Nanoscale clustering of RGD peptides at surfaces using comb polymers. 2. Surface segregation of comb polymers in polylactide. Biomacromolecules 2, 545-56 (2001). 15. Patel, N. et al. Spatially controlled cell engineering on biodegradable polymer surfaces. Faseb Journal 12, 1447- 1454 (1998). 16. Palecek, S. P., Loftus, J. C., Ginsberg, M. H., Lauffenburger, D. A. & Horwitz, A. F. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385, 537-40 (1997). Lecture 3 – Biological Recognition 15 of 15