Development of IBS pathophysiology Abnormalnetwork regulation IBS molecular biology Of nerve-immune-endocrine inflammation 5-HT mediated hypersensitivity and gut motility Brain-gut interaction Visceral hypersensitivity Abnormal motor function 195019601970198019902000Development of IBS pathophysiology ｛ inflammation 5-HT mediated hypersensitivity and gut motility Brain-gut interaction Visceral hypersensitivity Abnormal motor function 1950 1960 1970 1980 1990 2000 Abnormal network regulation Of nerve-immune-endocrine IBS molecular biology ……