2015,13,3182-3230)详细介绍。 weo28P otin)FDA 2011 Cance 0m S6aBso8cie V-V--V DA20 a068 òe0. 图1O-L.FDA或EMEA批准的米源于海洋的药物及应用 Pltdepsin(Aplidin 0104(ayps olid(Aurstatin PE) ILX-651 (tasidotin or synthadotin) 图10-2.进入期临床研究的海洋天然产物2015, 13, 3182~3230)详细介绍。 O H N N S O HO O HO NH2 O O O N NH O NH2 Ara-C Cancer FDA 1969 Ara-A Antiviral FDA 1976 N N NH2 N N Cephalosporin C FDA 1961 Antibiotics N NH N S O O H3C O O H3C H H OH HO CH3 O O O HO O H3C H3C CH3 H Et-743 (Trabectedin) UE 2007 Yondelis, Cancer H O O O O O O O H H H H O H H H H O MeO H2N OH Halaven (Eribulin) FDA 2010 Cancer O N O H N O N O O O N O H N O OH N H H MAB-Val-Cit Adcetris (Brentuximab vedotin) FDA 2011 Cancer EtO O EtO O EPA:DHA:esterified fish oils = 47:38:17 FDA 2004 Lovaza, Hypertriglyceridemia CKGKGAKCSRLMYDCCTGSCRSGKC-CONH2 Ziconotide (w-conotoxin) FDA 2004 Prialt, Pain O OH HO OH H H H H O OH HO OH H H H H O O O O OH OH OSO3 - OSO3 - - O3SO O Carragelose OTC Antiviral 图 10-1. FDA 或 EMEA 批准的来源于海洋的药物及应用 N H N N O O O N O O O H N H Soblidotin (Auristatin PE) N N O O DMBX (GTS-21) N H H N O O N NH Plinabulin (NPI-2358) H O N O N H HO H N O N H O N O HN O H2N H N O HN O O NH N H O O HN HN O NH O OO Elisidepsin (Irvalec) N O N H N N O O O N O HN ILX-651 (tasidotin or synthadotin) O O NH O NH N O O O OH N CH3 O O O NH O N N O O O O Plitidepsin (Aplidin) N N HN O O O H H OH HO O O O CH3 H F3C PM00104 (Zalypsis) 图 10-2. 进入 II 期临床研究的海洋天然产物