1.3. Developments of Mc Leading to various Medicinal Classes of Drugs During the 1840s, the first use of synthetic organic chemicals were introduced for anesthesia during a tooth removal, such as nitrous oxide, ether and chloroform In 1864, barbituric acid had been synthesized as a useful hypnotic• 1.3. Developments of MC Leading to Various Medicinal Classes of Drugs • During the 1840s, the first use of synthetic organic chemicals were introduced for anesthesia during a tooth removal, such as nitrous oxide, ether, and chloroform. • In 1864, barbituric acid had been synthesized as a useful hypnotic