In 1898, the first commercially available semisynthetic morphine derivative (ethyl ether) was introduced as a cough sedative in preference to codeine or other opiates Meanwhile, diacetylmorphine was introduced as a safer pain reliever than morphine. It quickly became popular throughout the world Four years passed before its addictive properties of heroin were recognized. Laws were later passed by governments to restrict its use• In 1898, the first commercially available semisynthetic morphine derivative (ethyl ether) was introduced as a cough sedative in preference to codeine or other opiates. • Meanwhile, diacetylmorphine was introduced as a safer pain reliever than morphine. It quickly became popular throughout the world. • Four years passed before its addictive properties of heroin were recognized. Laws were later passed by governments to restrict its use