BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Mimicking the silica deposition of diatoms Fig. 7. 15 Stages in the morphogenesis of the diatom frustule. See text for details. nanovesicles SDV-silica deposition vesicles AV- aleolar vesicles PL-plasmalemma(lipid bilayer cell wall) ER-endoplasmic reticulum Disk-shaped diatom 31 SSKKSGSYSGSGSKGSKRR Amine side chains Si substrate (Brott et al. 2001 Lecture 12-Inorganic Biomaterials 7of13BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Mimicking the silica deposition of diatoms nanovesicles SDV - silica deposition vesicles AV - aleolar vesicles PL - plasmalemma (lipid bilayer cell wall) ER - endoplasmic reticulum Disk-shaped diatom Silaffin cationic polypeptide lines SDVs and provides a nucleating surface for silica deposition in the diatom: SSKKSGSYSGSGSKGSKRR Amine side chains (Brott et al. 2001) Si substrate (tri-acrylate) Lecture 12 – Inorganic Biomaterials 7 of 13