Eab Clobazam Mechanism of action- benzodiazepine oA: activates GABA receptor a. Adjunctive treatment of Lennox-Gastaut seizures for patients >2 years o000oc0= Pharmacokinetics V=100L Active metabolite N-desmethylclobazam Metabolized by CyP2C19 decrease dose in poor metabolizers 1/2=36-42 hours(metabolite 71-82 hours) KENTUCKY College of PharmacyClobazam • Mechanism of action – benzodiazepine; activates GABA receptor • Adjunctive treatment of Lennox-Gastaut seizures for patients ≥ 2 years • Pharmacokinetics – Vd=100 L – Active metabolite N-desmethylclobazam – Metabolized by CYP2C19; decrease dose in poor metabolizers – t1/2=36-42 hours (metabolite 71-82 hours)