Thr NEW ENGLAND JOURNAL Of MEDICINE BetaCoV/Wuhan/IVDC-HB-01/2019EPI_ISL_402119(29892bp) ORF-lab 10h Nsp5 Nsp7 Nsp9 EM78 h31 TR Nsp2 Nsp3 Nsp13 Nspl4 Nspl5 Nsp16 Spike Nsp4 Receptor binding 3 E■+ M■ 7■+ 8 10b m 13■+ 14■ S-CoV 2018 113 G7729348*t SARS-lik 21 _HKU5 corona 9744 05010 AY391777 99 02 -月647n20 Figure4.Schematic of 2019-nCoV and Phylogenetic Analysis of 2019-nCoV and Other Betacoronavirus Genomes. N ENGLJ MED NEJM.ORC6 n engl j med nejm.org The new england journal o f medicine Figure 4. Schematic of 2019-nCoV and Phylogenetic Analysis of 2019-nCoV and Other Betacoronavirus Genomes. Shown are a schematic of 2019-nCoV (Panel A) and full-length phylogenetic analysis of 2019-nCoV and other betacoronavirus genomes in the Orthocoronavirinae subfamily (Panel B). A B AY508724|SARS_coronavirus_NS-1 AY485277|SARS_coronavirus_Sino1-11 AY390556|SARS_coronavirus_GZ02 AY278489|SARS_coronavirus_GD01 KT444582|SARS-like_coronavirus_WIV16 KY417146|Bat_SARS-like_coronavirus_Rs4231 KY417151|Bat_SARS-like_coronavirus_Rs7327 KY417152|Bat_SARS-like_coronavirus_Rs9401 MK211376|Coronavirus_BtRs-BetaCoV/YN2018B MK211377|Coronavirus_BtRs-BetaCoV/YN2018C MK211374|Coronavirus_BtRl-BetaCoV/SC2018 BetaCoV-Wuhan-IVDC-HB-04-2020 BetaCoV/Wuhan/IVDC-HB-01/2019|EPI_ISL_402119 BetaCoV-WuhanI-VDC-HB-05-2019EPI_ISL_402121 KY770859|Bat_coronavirus|Anlong-112 KJ473816|BtRs_BetaCoV/YN2013 KJ473815|BtRs_BetaCoV/GX2013|BtRs-GX2013 JX993988|Bat_coronavirus_Cp/Yunnan2011 KY417145|Bat_SARS-like_coronavirus_Rf4092 KY417142|Bat_SARS-like_coronavirus|As6526 KY417148|Bat_SARS-like_coronavirus|Rs4247 MG772934|Bat_SARS-like_coronavirus|bat-SL-CoVZXC21 KF636752|Bat_Hp-betacoronavirus/Zhejiang2013 EF065513|Bat_coronavirus_HKU9-1|BF_005I EF065505|Bat_coronavirus_HKU4-1|B04f KU762338|Rousettus_bat_coronavirus|GCCDC1_356 EF065509|Bat_coronavirus_HKU5-1|LMH03f JX869059|Human_betacoronavirus_2c_EMC/2012|HCoV-EMC KC545386|Betacoronavirus_Erinaceus/VMC/DEU/2012| ErinaceusCoV/2012-216/GER/2012 KM349744|Betacoronavirus_HKU24|HKU24-R05010l AY391777|Human_coronavirus_OC43|ATCC_VR-759 MK167038|Human_coronavirus_HKU1|SC2521 FJ647223|Murine_coronavirus_MHV-1|MHV-1 MG772933|Bat_SARS-like_coronavirus|bat-SL-CoVZC45 SARS-CoV MERS-CoV Sarbecovirus Hibecovirus Nobecovirus Merbecovirus Embevovirus 0.2 100 100 100 100 83 66 84 60 90 94 100 100 100 100 100 100 100 100 100 96 99 100 Nsp1 Nsp2 Nsp3 Nsp4 Nsp7 Nsp9 Nsp12 Nsp8 Nsp6 Nsp13 Nsp14 Nsp15 Nsp16 Nsp10 Nsp5 >BetaCoV/Wuhan/IVDC-HB-01/2019|EPI_ISL_402119 (29892 bp) UTR 5´ polyA 3´ Spike Receptor binding Enzyme 3 E M 78 1314 8 10b 7 M E 3 10b 13 14 N ORF-1ab