2. The mechanisms of nsaids Arachidonic acid esterified in membrane phospholipids Free radicals Diverse physical, chemical inflammatory and mitogenic stimuli Phospholipase A2 eicosatrienoic acids Isoprostanes EETS 9865 COOH Cytochrome P450 AA(204csD5,8,1114) 20 11121415 19 Lipoxygenases Cyclooxygenases (LOX) HETEs Prostaglandins Leukotrienes Prostacyclin 7 Prostanoids Lipoxins Thromboxane2. The mechanisms of NSAIDs